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No. 859 258, 524 ; Authors : Pootrakul P, Sirankapracha P, Sankote J, Kachintorn U, Maungsub W, Sriphen K, Thakernpol K, Atisuk K, Fucharoen S, Chantraluksri U, Shalev O, Hoffbrand AV. Title : Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia haemoglobin E patients in Thailand. Source : British Journal of Haematology. 122 2 ; : 305-10, 2003 Jul ; . Keywords : Deferiprone, Iron chelation, Haemoglobin E, Thalassaemia intermedia. Abstract : Nine patients with either beta-thalassaemia haemoglobin E 7 ; or homozygous beta-thalassaemia 2 ; not requiring regular transfusions were treated with the oral iron chelator, deferiprone 25-50 mg kg d for between 17 and 86 weeks mean 49 weeks ; . There were significant decreases in serum ferritin initial mean + - standard deviation 2168 + - 1142, final 418 + - 247 mug l; t -test for paired samples, P 0.005 ; , hepatic iron initial 20.3 + - 6.26, final 11.7 + - 4.83 mg g dry weight; P 0.02 ; , red cell membrane iron initial 76.2 + - 3.64, final 7.2 + - 0.56 mmol mg protein; P 0.0005 ; and serum non-transferrin bound iron initial 9.0 + - 0.56, final 5.9 + - 0.89 mumol l; P 0.0005 ; . There was also a significant rise in serum erythropoietin initial 240 + - 195.1, final 433.2 + - 269.2 U l; P 0.034 ; . The haemoglobin level rose in three patients and transfusion requirements were reduced substantially in four patients. Serum thiobarbituric acid reactive substance TBARS ; also fell in six of eight patients. Patients generally improved clinically, with weight gain observed. Side-effects were mild and included gastrointestinal symptoms 6 ; and arthralgia 1 ; , not requiring withdrawal of the drug. One patient died at 17 weeks of therapy as a result of an intercurrent infection. His neutrophil count was normal. We conclude that deferiprone is an effective, well-tolerated iron chelator for patients with thalassaemia intermedia. Further studies are needed to determine the optimum dose and length of treatment needed to reduce iron burden to a safe level in these patients and cimetidine.
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