Varies. As a group, the five AS imprinting mutation patients described here have the typical neurobehavioral pattern and cannot easily be distinguished from patients in other AS classes, although it must be noted that only 2 5 of these AS imprinting mutation patients have microcephaly and none has hypopigmentation Table II ; . The two sibs from the new PWS family, PWS-S, fulfill the criteria for classical PWS Table III ; , as with the previously described affected individuals in the PWS-U [Lubinsky et al., 1987] and PWS-O [rstavick et al., 1992] families. All affected individuals in each of these families score 910.5 points on the PWS consensus diagnostic criteria scale, where a score of 8 is required for diagnosis [Holm et al., 1993]. None of the affected patients with PWS or AS in these families has hypopigmentation Tables II, III ; . However, hypopigmentation in these disorders appears to be associated with deletion [Butler et al., 1986] of the non-imprinted P gene [Lee et al., 1994; Spritz et al., submitted], and thus imprinting mutation patients would be expected.
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Logan RF, Fraser GM, Ferguson A, Sircus W. A limited, direct access endoscopy service for general practitioners. Health Bull 1982; 40: 927. Mann J, Holdstock G, Harman M, Machin D, Loehry CA. Scoring system to improve cost effectiveness of open access endoscopy. BMJ 1983; 287: 93740. Rutter MD, Michie AF, Trewby PN. The one-stop dyspepsia clinic an alternative to open-access endoscopy for patients with dyspepsia. J R Soc Med 1998; 91: 5247.
Doubilet P. Weinstein MC, McNeil BJ. Use and misuse of the term "cost effective" in medicine. N Engl J Med 1986; 314: 253-254. Relman A. Medicine as business: are doctors entrepreneurs? Science 1 986; 233: Abrams FR. Patient advocate or secret agent? JAMA 1986; 256: 1784-1786. May WE. On ethics and advocacy. JAMA 1986; 256: 1786-1787. Swick M. Darstellung der Niere und Hamwege im Rontgenbild durch intravenose embringung eines neuen Kontraststoffes, des Uroselectans. Klin Wschr 1929; 8: 2087-2089. Osborne ED, Sutherland CC, Scholl AJ Jr and ponstel, for instance, drugs.
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Ganslandt M, .Maskus K. Parallel Imports of Pharmaceutical Products in the European Union - Working Paper 546 2001. The Research Institute of Public Economics 2001. Association of the British Pharmaceutical Industry, The Department of Health. PPRS: The Study into the Extent of Competition in the Supply of Branded Medicines to the NHS. DOH, 2002. Stichting Farmaceutische Kengetallen Foundation for Pharmaceutical Statistics S. Facts and Figures 2002. Pharmaceutical Industry Competitiveness Task Force. Access and Competitiveness Study. 2001. Kanavos P. The Single Market for Pharmaceuticals in the European Union in Light of European Court of Justice Rulings. Pharmacoeconomics 2000; 18 6 ; : 523-32. Macarthur D. The Growing Influence of the Pharmacist in Europe. 1995. Financial Times Pharmaceutical and Healthcare Publishing. Towse A. The Pros and Cons of a Single "Euro-Price" for Drugs. Pharmacoeconomics 1998; 13: 271-6. Towse A. The UK Pharmaceutical Market: An Overview. Pharmacoeconomics 1996; 10: 1425. Danzon P. The Economics of Parallel Trade. Pharmacoeconomics 1998; 13: 293-304. OXERA Consulting Limited. Fundamental Review of the Generic Drugs Market. 2001. FOCUS . 18-10-2001. International Federation of Pharmaceutical Wholesalers. Fakta 2002 - Pharmaceutical Market and Healthcare. 2002 and reglan.
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