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Largely independent, functionally and biochemically distinct, with the nervous system seeming more hard-wired and the immune system more reactive. Now, researchers are seeing at the biochemical and cellular levels how these systems relate in ways we never imagined. Why are collaborations between scientists in the two fields just now becoming the recognized strategy for moving the field forward? One part of the answer is that technological advances are revealing new leads that require the brain power and tools of both fields to fully exploit. Another part of the answer may be that these early collaborations have required the investigators from each of the two fields to question long-held assumptions within their respective disciplines. Neuroimmunology, as the name implies, requires a convergence of perspectives. For example, we have known for about a century that nerve cells communicate with one another through connections called synapses. Now it is apparent that immune cells also communicate with one another through synapse-like junctions that appear to share some common features with nerve cell synapses, including some molecules in common. And there is new evidence to suggest that brain cell synapses are influenced by immune reactions in the brain. Another revelation is that the same molecule that is involved in cell-to-cell recognition in the immune system also has a major role in the brain's "wiring" process. This molecule is called "major histocompatability complex, " referred to as MHC. In the immune system, MHC molecules take a fragment of an invading pathogen's peptides and display it to certain immune cells so they can learn to identify the pathogen and attack it. In the developing nervous system, Harvard Medical School scientist Carla Shatz and her colleagues recently found, MHC molecules appear to be essential for one brain cell to determine which other brain cell to connect to as the brain.
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