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1562 MHC alleles, or MHC incompatibilities were noted. Could donor T cells have contributed to this pattern i.e., altered V repertoire ; ? Thus far, there is no direct evidence available in the literature. However, donor cell chimerism has been detected years after kidney transplantation 48 ; at levels as low as 1: 100, 000 donor to recipient cells by PCR sequence-specific primers SSP ; using the Y chromosome as a target. In the present study, no circulating donor cells could be detected by PCR-SSP performed on HLA-DR targets in four patients for whom PBL harvested at the time of the experiment were available patients CS, LJM, VJ, and DD, data not shown ; . Based on this finding, it is likely that the altered V repertoire observed in this study was due to recipient T cells alone. Nonrestricted public CDR3 sequences found in the common V 8-J 1.4 alteration in several recipients does not preclude the possibility that the corresponding V chains do not interact with identical determinants. Indeed, the cross-reactive nature of TCR recognition is now a well-accepted concept 49, 50 ; , and situations where TCR with similar CDR3 sequences interact with different peptides or, alternatively, where V -chains of different CDR3 sequences interact with a single determinant are increasingly reported 51, 52 ; . Furthermore, identical V TCR sequences shared by T lymphocytes infiltrating the graft of several animals, even in a congeneic combination, were the exception 53, 54 ; and were almost restricted to a single donor-specific transfusion-induced tolerance 55 ; . However, the above-mentioned high cross-reactive nature of the TCR makes any interpretation at this stage difficult, and one cannot exclude the fact that positively selected clones with the observed V alterations could also recognize viruses known to frequently infect long-term graft recipients. Highly altered V repertoires with oligoclonal V expansions have also been described in the peripheral blood of patients infected by HIV 31 ; , of healthy individuals infected by EBV 42 ; , and in patients with chronic infection with hepatitis B virus 43 ; . Because CMV infections are frequent after transplantation 8 ; , oligoclonal and common TCR expansions could also have been directed against CMV-derived peptides. However, TCR clones have only been found to be expanded during CMV infection 41 ; , and -positive T cells represented a tiny minority 1% ; of infiltrating cells in our patients. Furthermore, we were unable to identify TCR- alterations mimicking the common and oligoclonal patterns found in the grafts studied when peripheral TCR repertoires in four patients were analyzed, with the same method, following an unambiguous overt CMV disease. Finally, neither the clinical CMV infections nor the finding of viral genome CMV, HSV, HHV6, human papillomavirus, and EBV ; correlated with a V -C or oligoclonal expansion found in the kidneys could sustain, at this stage, a rationale for the hypothesis of viral-driven TCR alterations. Furthermore, none of the published characteristics or sequences of virusdriven TCR alteration reported in humans 42 ; were noted in the altered V transcripts derived from the rejected grafts studied. Nevertheless, it is noteworthy that the most altered family with common V -J rearrangement ; was found to be the V 8 family. An increased V 8 usage has been reported not only in an autoimmune disease with a potentially viral etiology 56 ; , or following superantigen stimulation 57 ; , but also in peripheral T lymphocytes of kidney graft recipients 14 ; . However, no analysis of V CDR3 lengths or of association with specific J was performed in the referred studies. Furthermore, our study not only showed an altered V 8 family profile, but also provided a quantitative indication of the strong accumulation of V 8 mRNA increased up to 120-fold ; , further suggesting a positive selection of the corresponding clones. Finally, an elegant demonstration that in an experimental model of heart allotransplantation the presence of the chronically rejected.
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Thrombosis and myocardial infarction. Circulation 1999; 99: 14111415. Ingolfsson IO, Sigurdsson G, Sigvaldason H, Thorgeirsson G, Sigfusson N. Marked decline in the prevalence and incidence of intermittent claudication in Icelandic men 1968 1986: a strong relationship to smoking and serum cholesterol--the Reykjavik Study. J Clin Epidemiol 1994; 47: 12371243. Quick CR, Cotton LT. The measured effect of stopping smoking on intermittent claudication. Br J Surg 1982; 69 suppl ; : S24 S26. Jonason T, Bergstrom R. Cessation of smoking in patients with intermittent claudication: effects on the risk of peripheral vascular complications, myocardial infarction and mortality. Acta Med Scand 1987; 221: 253260. Ameli FM, Stein M, Provan JL, Prosser R. The effect of postoperative smoking on femoropopliteal bypass grafts. Ann Vasc Surg 1999; 3: 20 American Diabetes Association. Peripheral arterial disease in people with diabetes. Diabetes Care 2003; 26: 3333 Hirsch AT, Criqui MH, Treat-Jaconson D, et al. Peripheral arterial disease detection, awareness and treatment in primary care. JAMA 2001; 286: 1317 Meijer WT, Grobbee DE, Hunink MG, Hofman A, Hoes AW. Determinants of peripheral arterial disease in the elderly: the Rotterdam study. Arch Intern Med 2000; 160: 2934 Newman AB, Siscovick DS, Manolio TA, et al. Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study CHS ; Collaborative Research Group. Circulation 1993; 88: 837 Muluk SC, Muluk VS, Kelley ME, et al. Outcome events in patients with claudication: a 15-year study in 2777 patients. J Vasc Surg 2001; 33: 251257. Pomrehn P, Duncan B, Weissfeld L, et al. The association of dyslipoproteinemia with symptoms and signs of peripheral arterial disease. The Lipid Research Clinics Program Prevalence Study. Circulation 1986; 73 suppl ; : I100 I107. National Cholesterol Education Program NCEP ; Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III ; . Third Report of the National Cholesterol Education Program NCEP ; Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III ; final report. Circulation 2002; 106: 3143, because ovcon 35.
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And God, the active principle par excellence. Posidonius seems to offer a nondualistic and materialistic approach to the concept of `substance'. As to the philosophical goal aimed at by him, a reasonable hypothesis is also advanced: although he does not change anything in the ontological dogmata of his Stoic teachers, he tried perhaps to underline the unity of `quality' and `matter' or God and matter ; , because he wanted to attack the dualistic metaphysics of the Platonic tradition. The very controversial question of the actual sources of Posidonius' solution is also examined by Alesse; without assuming any prejudicial stance, she is able to indicate some possible influences due to Aristotle's lexicon and conceptual framework. Also the role of other philosophical schools can help to understand the atmosphere of great exchange of ideas and theoretical inquiries in this period. It is the case of the Epicurean community, and particularly of Philodemus' thought, whose place both inside the Garden and with regards often polemically to other schools was examined in its ethical, psychological and methodological characteristics by Voula Tsouna Philodemus of Gadara and the Epicurean Tradition: Remarks on Ethics, Moral Psychology, and Method ; . Her rich paper commented not only on some scanty evidence relative to moral tenets of the Epicurean school, but also on the more interesting question of the philosophical coherence of its hedonism. In his arguments from the point of view of both the content and the methodological strictures Philodemus depended, as it seems, especially from Zeno of Sidon and less from Demetrius Lacon ; and maintained a rigorous sense of reverence towards Epicurus. At any rate, he wanted to consolidate the main teachings of the founder of the school and at the same time to grant their transmission to posterity. In doing that he did not limit himself to a list of advices and sayings practically orientated, but exhibited a high level of theoretical consciousness. As to the sceptical movement, a scholarly `puzzle' of Aenesidemus' philosophy, namely his alleged `Heracliteanism', received a new critical assessment by Malcom Schofield Aenesidemus: Pyrrhonist and `Heraclitean' ; . Schofield was convinced that Aenesidemus did not endorse in propria persona all of Heraclitus' doctrines, although the founder of neo-pyrrhonism did not assume a completely detached attitude towards them. Accordingly, in most of his paper Schofield tried to explain and refine also thanks to some large assumptions the general hypothesis that somewhere Aenesidemus wrote a `sympathetic' defence of Heracliteanism, considered by him as a philosophical stance well supported, from a sceptical point of view, by observations and arguments on the situation of conflicting appearances. This kind of revised Heracliteanism could also provide him with an appropriate metaphysical doctrine on the nature of the universe, a sort of `theory of reality', which was theoretically useful for sustaining the Aenesidemean appeal to nonconflicting phainomena.
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